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http://www.portailsig.org/content/python-utilisation-des-couches-vectorielles-et-matricielles-dans-une-perspective-geologique- (it is in French, you may need to use google translate)

INPUT

1. 2d line shapfile contains the line string (e.g. river)
2. DEM data (or any rater data with variable)
3. interval of length 

OUPUT

1. csv data with two columns (length, elevation (or variable))
2. example profile chart